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The infection persists and causes cancer in only a small minority. Two vaccines are approved to prevent HPV infection and are recommended for people before they become sexually active. The vaccine does not work in people who are already infected. Dr. Fujise studied 2, women, ages 20 to 59, who took part in a national health survey from to. The women used vaginal swabs to provide specimens for HPV testing and reported whether they had heart disease, which was defined in this study as ever having suffered a heart attack or stroke. In all, 1, women had HPV. Sixty women had heart disease; of those, 39 also had HPV. When the researchers analyzed the data and adjusted for heart risks like smoking, blood pressure and weight, they found that women with HPV were times as likely as those without the virus to have heart disease. The risk was even higher, times that of uninfected women, in those who had HPV strains known to cause cancer. Dr. Fujise said the results surprised him. “I was thinking maybe there would be just a weak link or no link, but this is a strong link,” he said. Even if further research confirms the connection, most people who contract HPV would not be at special risk for heart disease. Dr. Fujise said that if the link is real, heart disease, like cancer, would be likely to develop only in people with lingering HPV infection. A researcher not involved with the study, Dr. Mosca, director of preventive cardiology at NewYork-Presbyterian Hospital/Columbia University Medical Center, said: “I’m definitely intrigued by this. The biological argument is highly plausible and deserves further investigation.” But she emphasized that plausibility is not enough; the history of medicine is full of ideas that made sense and turned out to be wrong. The type of study that Dr. Fujise did, in which scientists look for associations in a mass of data, is good for generating ideas for more research, but it does not prove cause and effect. Finding an association does not even tell which condition came first. In theory, heart disease could have come first and made the women more vulnerable to HPV. Or some other unknown factor could have predisposed some women to both HPV and heart disease. mature date in Kontiola
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