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HIV cure is the next frontier Johnston (-: Highleyman) Prevention was the biggest AIDS theme of , with new study findings showing that early antiretroviral treatment can reduce the risk of HIV transmission by nearly percent, and data demonstrating that pre-exposure prophylaxis, or PrEP, can significantly reduce infection – at least for some people, some of the time. But researchers and advocates are looking beyond the latest advances in antiretroviral therapy and biomedical prevention toward a goal that not ago was considered too far-fetched to warrant serious discussion: a cure for HIV. "Cure is the next frontier," said Johnston, vice president for research at amfAR, the Foundation for AIDS Research. "We want to make 'cure' into a family-friendly letter word." AmFAR has put its money where its mouth is, recently announcing $ million in awards with an emphasis on cure-focused research; among the 13 grants, went to researchers in San. The funding also cover fellowships to support promising researchers in the HIV/AIDS field. The resurgence in cure-related research in recent years has come from the realization that, even with today's highly effective antiretroviral, people not be able to treat their way out of the epidemic. "Antiretrovirals are good, but people have to adhere to them for a lifetime, they are costly, and they have side effects," Johnston told the Bay Area Reporter. Further impetus was provided by the "Berlin patient," San resident Brown, who appears to have been cured of HIV after receiving two bone marrow transplants to treat leukemia, using stem cells from a donor with naturally resistant CD4 T-cells. While the grueling and expensive transplant procedure is not suited for widespread use, it offers clues about how cells might be protected from the virus – clues that have spurred efforts to recreate this effect using therapy to artificially remove an HIV receptor known as CCR5 from patients' T-cells. FULL STORY: shag my wife in Dutch Harbor Alaska
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